反应详情

温度

100 °C

A solution of 2-amino-5-fluorobenzoic acid (9.29 mmol, 1.440 g) in a mixture of HCl/MeOH (3N, 30 ml) was heated at 100° C. overnight. The solvent was evaporated and the crude mixture was extracted between DCM and K2CO3 saturated aqueous solution. The organic phase was evaporated and the crude mixture was purified by chromatography over SiO2 with hexane/ethyl acetate mixtures affording 0.650 g (yield 42%) of the expected product.

1. customThe solvent was evaporated
2. extractionthe crude mixture was extracted between DCM and K2CO3 saturated aqueous solution
3. customThe organic phase was evaporated
4. customthe crude mixture was purified by chromatography over SiO2 with hexane/ethyl acetate