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0 °C

Sodium bicarbonate (5.62 g, 66.87 mmol) was added to a solution of sodium sulfide (5.5 g, 70.58 mmol) in deionized water (60 mL). When the sodium bicarbonate was completely dissolved, methanol (50 mL) was added, and the solution was cooled to 0° C. A precipitate formed, which was removed by filtration through a Celite pad. The filtered solution was added quickly to a solution of 3,5-dinitroanisole (7.36 g, 37.15 mmol) in methanol (50 mL). The resulting suspension was heated to reflux for 30 min and then the solution was concentrated in vacuo to remove methanol. The aqueous residue was poured into 200 mL of ice-water, and the resulting orange precipitate was collected by filtration. After air-drying, 3-methoxy-5-nitro-phenylamine (5.82 g, 93%) was obtained as light brown solid: ES(+)-HRMS m/e calculated for C7H8N2O3 (M+H)+ 169.0608, found 169.0608.

1. customA precipitate formed
2. customwhich was removed by filtration through a Celite pad
3. temperatureThe resulting suspension was heated
4. temperatureto reflux for 30 min
5. concentrationthe solution was concentrated in vacuo
6. customto remove methanol
7. additionThe aqueous residue was poured into 200 mL of ice-water
8. filtrationthe resulting orange precipitate was collected by filtration
9. customAfter air-drying