Sodium Hydroxide → 4-{2-(2-Carboxyethyl)-3-[6-(5-thiophen-3-ylbiphenyl-3-yloxy)-hexyl]phenoxy}butyric Acid

Participants

Reaction Steps

A similar procedure as described in Example 12, step 9 was used, starting from 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(5-thiophen-3-yl-biphenyl-3-yloxy)-hexyl]-phenoxy}-butyric acid ethyl ester (85 mg, 0.13 mmol) and 1.0 N aqueous NaOH (8 mL) to afford 4-{2-(2-carboxy-ethyl)-3-[6-(5-thiophen-3-yl-biphenyl-3-yloxy)-hexyl]-phenoxy}-butyric acid (55 mg, 71%) as an amorphous white solid: ES(+)-HRMS m/e calculated for C35H38O6S (M+H)+ 587.2462, found 587.2461.

Provenance & Evidence