(Pyridin-4-yl)boronic acid → 4-{2-(2-Ethoxycarbony-ethyl)-3-[6-(3-pyridin-4-yl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester

Participants

Reaction Steps

A similar procedure as described in Example 12, step 8 was used, starting from 4-{3-[6-(3-iodo-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy}-butyric acid ethyl ester (207 mg, 0.3 mmol) and pyridin-4-ylboronic acid (123 mg, 1.0 mmol) to obtain 4-{2-(2-ethoxycarbony-ethyl)-3-[6-(3-pyridin-4-yl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester (120 mg, 62%) as an yellow oil: ES(+)-HRMS m/e calculated for C38H45NO6S (M+H)+ 644.3041, found 644.3041.

Provenance & Evidence