Sodium Hydroxide → 4-{2-(2-Carboxy-ethyl)-3-[6-(3-pyridin-4-yl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid

Participants

Reaction Steps

A similar procedure as described in Example 12, step 9 was used, starting from 4-{2-(2-ethoxycarbony-ethyl)-3-[6-(3-pyridin-4-yl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester (114 mg, 0.18 mmol) and 1.0 N aqueous NaOH (6 mL) to afford 4-{2-(2-carboxy-ethyl)-3-[6-(3-pyridin-4-yl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid (95 mg, 91%) as an amorphous white solid: ES(+)-HRMS m/e calculated for C34H37NO6S (M+H)+ 588.2415, found 588.2414.

Provenance & Evidence