(Pyrimidin-5-yl)boronic acid → 4-{2-(2-Ethoxycarbonyl-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester

Participants

Reaction Steps

A similar procedure as described in Example 12, step 8 was used, starting from 4-{3-[6-(3-iodo-5-thiophen-3-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy}-butyric acid ethyl ester (207 mg, 0.3 mmol) and pyrimidin-5-ylboronic acid (124 mg, 1.0 mmol) to obtain 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester (142 mg, 73%) as a light yellow viscous oil: ES(+)-HRMS m/e calculated for C37H44N2O6S (M+H)+ 645.2993, found 645.2987.

Provenance & Evidence