Sodium Hydroxide → 4-{2-(2-Carboxy-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid

Participants

Reaction Steps

A similar procedure as described in Example 12, step 9 was used, starting from 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester (137 mg, 0.21 mmol) and 1.0 N aqueous NaOH (6 mL) to give 4-{2-(2-carboxy-ethyl)-3-[6-(3-pyrimidin-5-yl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid (115 mg, 93%) as an amorphous light yellow solid: ES(+)-HRMS m/e calculated for C33H36N2O6S (M+H)+ 589.2367, found 589.2366.

Provenance & Evidence