(2H-1,3-benzodioxol-5-yl)boronic acid → HCID 25192471, compound

Participants

Reaction Steps

A similar procedure as described in Example 5, step 2 was used, starting from 4-{2-(2-carboxy-ethyl)-3-[6-(3′-fluoro-5-iodo-biphenyl-3-yloxy)-hexyl]-phenoxy}-butyric acid (1.2 g, 1.85 mmol) and benzo[1,3]dioxol-5-yl-boronic acid (614 mg, 3.7 mmol) to obtain 4-{3-[6-(5-benzo[1,3]dioxol-5-yl-3′-fluoro-biphenyl-3-yloxy)-hexyl]-2-(2-carboxy-ethyl)-phenoxy}-butyric acid (737 mg, 62%) as an amorphous white solid: ES(+)-HRMS m/e calculated for C38H39FO8 (M+Na)+ 665.2521, found 665.2520.

Provenance & Evidence