3-Iodo-5-nitrophenol → 4-{2-(2-Ethoxycarbonyl-ethyl)-3-[6-(3-iodo-5-nitro-phenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester

Participants

Reaction Steps

A similar procedure as described in Example 12, step 7 was used, starting from 4-[3-(6-bromo-hexyl)-2-(ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (9.39 g, 19.92 mmol) and 3-iodo-5-nitro-phenol (4.8 g, 18.11 mmol) to afford 4-{2-(2-ethoxycarbonyl-ethyl)-3-[6-(3-iodo-5-nitro-phenoxy)-hexyl]-phenoxy}-butyric acid ethyl ester (8.7 g, 73%) as a light yellow oil: ES(+)-HRMS m/e calculated for C29H38INO8 (M+H)+ 656.1715, found 656.1721.

Provenance & Evidence