Ammonium Chloride → 4-{3-[6-(3-Amino-5-benzo[1,3]dioxol-5-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy}-butyric acid ethyl ester

Participants

Reaction Steps

A similar procedure as described in Example 12, step 4 was used, starting from 4-{3-[6-(3-benzo[1,3]dioxol-5-yl-5-nitro-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy}-butyric acid ethyl ester (4.8 g, 7.38 mmol), zinc dust (2.46 g, 36.94 mmol), and ammonium chloride (3.95 g, 73.88 mmol) to obtain 4-{3-[6-(3-amino-5-benzo[1,3]dioxol-5-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy}-butyric acid ethyl ester (3.99 g, 87%) as a light yellow oil: ES(+)-HRMS m/e calculated for C36H45NO8 (M+H)+ 619.0000, found 619.0000.

Provenance & Evidence