反应详情

温度

100 °C

A mixture of 2-(tert-butoxycarbonylamino)-5-(trifluoromethyl)benzoic acid (7.21 mmol, 2.2 g), H2SO4 (36 mmol, 1.92 ml) in ethanol (25 ml) was stirred at 100° C. for 16 hours. The solvent was evaporated, water was added, pH was taken to 6 and extracted with CHCl3. The crude mixture was purified by chromatography over SiO2 eluting with DCM/MeOH mixtures and affording 0.69 g (yield 41%) of the expected product.

1. customThe solvent was evaporated
2. additionwater was added
3. extractionextracted with CHCl3
4. customThe crude mixture was purified by chromatography over SiO2 eluting with DCM/MeOH mixtures