(Pyrimidin-5-yl)boronic acid → HCID 68750403, compound

Participants

Reaction Steps

A similar procedure as described in Example 12, step 8 was used, starting from 4-{3-[6-(3-benzo[1,3]dioxol-5-yl-5-iodo-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy}-butyric acid ethyl ester (47 mg, 0.06 mmol) and pyrimidin-5-ylboronic acid (32 mg, 0.26 mmol) to afford 4-{3-[6-(3-benzo[1,3]dioxol-5-yl-5-pyrimidin-4-yl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy-butyric acid ethyl ester (31 mg, 71%) as a light yellow oil: ES(+)-HRMS m/e calculated for C40H46N2O8 (M+H)+ 683.3327, found 683.3327.

Provenance & Evidence