4-Fluorophenylboronic acid → HCID 86628188, compound

Participants

Reaction Steps

A similar procedure as described in Example 22, step 2 was used, starting from 4-[3-{6-[3-bromo-5-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-phenoxy]-hexyl}-(2-(2-ethoxycarbonyl-ethyl)-phenoxy)-butyric acid ethyl ester (189 mg, 0.27 mmol) and 4-fluoro-phenylboronic acid (114 mg, 0.82 mmol) to obtain 4-[3-{6-[5-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-4′-fluoro-biphenyl-3-yloxy]-hexyl}-(2-(2-ethoxycarbonyl-ethyl)-phenoxy)-butyric acid ethyl ester (65 mg, 34%) as a light yellow oil: ES(+)-HRMS m/e calculated for C43H49FO8 (M+Na)+ 735.3303, found 735.3298.

Provenance & Evidence