Sodium Hydroxide → HCID 25192024, compound

Participants

Reaction Steps

A similar procedure as described in Example 22, step 3 was used, starting from 4-[3-{6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-4-yl-phenoxy]-hexyl}-2-(2-ethoxycarbonyl-ethyl)-phenoxy)-butyric acid ethyl ester (75 mg, 0.1 mmol) and 1.0 N aqueous sodium hydroxide (6 mL) to afford 4-(2-(2-carboxy-ethyl)-3-{6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-4-yl-phenoxy]-hexyl}-phenoxy)-butyric acid (55 mg, 86%) as an amorphous off-white solid: ES(+)-HRMS m/e calculated for C38H41NO8 (M+H)+ 640.2905, found 640.2899.

Provenance & Evidence