Sodium Hydroxide → HCID 86628191, compound

Participants

Reaction Steps

A similar procedure as described in Example 1, step 3 was used, starting from 4-[3-{6-[3-benzo[1,3]dioxol-5-yl-5-(1,6-dimethyl-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridin-3-yl)-5-thiophen-3-yl-phenoxy]-hexyl}-(2-(2-ethoxycarbonyl-ethyl)-phenoxy)-butyric acid ethyl ester (15 mg, 0.018 mmol) and 1.0 N aqueous sodium hydroxide (2 mL) to afford 4-[3-{6-[3-benzo[1,3]dioxol-5-yl-5-(1,6-dimethyl-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridin-3-yl)-5-thiophen-3-yl-phenoxy]-hexyl}-(2-(2-carboxy-ethyl)-phenoxy)-butyric acid (12 mg, 86%) as an amorphous off-white solid: ES(+)-HRMS m/e calculated for C40H42F3NO9 (M+H)+ 738.2885, found 738.2884.

Provenance & Evidence