反应详情

A suspension of pyridinium chlorochromate (8.28 g, 38.4 mmol) and dry celite (5.00 g) in dry dichloromethane was stirred at room temperature for 15 min. 2-Iodobenzyl alcohol (3.03 g, 12.9 mmol) in dry dichloromethane (50 ml) was added. The suspension was shielded from light and stirred at room temperature for 2 h after which it was diluted with ether, and filtered through celite. The cloudy brown filtrate was concentrated to a red-brown gummy solid which was dissolved in dichloromethane and passed through a short silica column, eluting with dichloromethane. The solution was concentrated to give 2-iodobenzaldehyde (19) as a pale yellow oil (2.87 g, 95%).

1. dry with materialdry celite (5.00 g) in dry dichloromethane
2. stirringstirred at room temperature for 2 h after which it
3. filtrationfiltered through celite
4. concentrationThe cloudy brown filtrate was concentrated to a red-brown gummy solid which
5. dissolutionwas dissolved in dichloromethane
6. washeluting with dichloromethane
7. concentrationThe solution was concentrated