HCID 66658645, compound → HCID 54741065, compound

HRID 420447Notes

Reaction equation

HRID 420447 reaction equation
C([O:5][C:6](=[O:27])[CH2:7][NH:8][C:9]([C:11]1[C:23](=[O:24])[N:22]([CH3:25])[C:14]2[N:15]=[N:16][C:17]([C:19]([OH:21])=[O:20])=[CH:18][C:13]=2[C:12]=1[OH:26])=[O:10])(C)(C)C.ClC1N=NC2N(C)C(=O)C(C(NCC(OC(C)(C)C)=O)=O)=C(O)C=2C=1>[Pd]>[C:6]([CH2:7][NH:8][C:9]([C:11]1[C:23](=[O:24])[N:22]([CH3:25])[C:14]2[N:15]=[N:16][C:17]([C:19]([OH:21])=[O:20])=[CH:18][C:13]=2[C:12]=1[OH:26])=[O:10])([OH:27])=[O:5]

Participants

4

Reactant 2

HCID 66658645HCID 66658645, compoundHCID 86629414HCID 86629414, compound

Product 1

HCID 54741065HCID 54741065, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst2×

Procedure

6-((2-tert-Butoxy-2-oxoethyl)carbamoyl)-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-c]pyridazine-3-carboxylic acid. The title compound is prepared by a palladium catalyzed carbonylation reaction of tert-butyl 2-(3-chloro-5-hydroxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxamido)acetate according to the procedure of Tsuji, J., Palladium Reagents and catalysts: Innovations in Organic Synthesis Publisher: (Wiley, Chichester, UK), 340-45 (1995).

Sources & evidence

ORD record
ord-e45fbbdb912e49df9ee44684c7562b1d
Source dataset
uspto-grants-2012_01
Patent number
US08097620B2

Reaction notes

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