Glycine tert-butyl ester hydrochloride → HCID 54741072, compound

HRID 420450Notes

Reaction equation

HRID 420450 reaction equation
[OH:1][C:2]1[C:11]2[CH:10]=[C:9]([O:12][CH3:13])[N:8]=[N:7][C:6]=2[N:5]([CH3:14])[C:4](=[O:15])[C:3]=1[C:16]([NH:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])=[O:17].OC1C2C=C(OC)N=NC=2N(C)C(=O)C=1C(OC)=O.Cl.NCC(OC(C)(C)C)=O>>[OH:1][C:2]1[C:11]2[CH:10]=[C:9]([O:12][CH3:13])[N:8]=[N:7][C:6]=2[N:5]([CH3:14])[C:4](=[O:15])[C:3]=1[C:16]([NH:18][CH2:19][C:20]([OH:22])=[O:21])=[O:17]

Participants

4

Reactant 3

HCID 2725036Glycine tert-butyl ester hydrochlorideHCID 66658610HCID 66658610, compoundHCID 66658767HCID 66658767, compound

Product 1

HCID 54741072HCID 54741072, compound

Procedure

tert-Butyl 2-(5-hydroxy-3-methoxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxamido)acetate. The title compound is prepared from methyl 5-hydroxy-3-methoxy-8-methyl-7-oxo-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxylate and tert-butyl 2-aminoacetate hydrochloride according to Method 3(a).

Sources & evidence

ORD record
ord-eb84f7cadeba40769c3c3b7e1ec7c8b9
Source dataset
uspto-grants-2012_01
Patent number
US08097620B2

Reaction notes

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