Glycine tert-butyl ester hydrochloride → HCID 54741073, compound

HRID 420452Notes

Reaction equation

[OH:1][C:2]1[C:11]2[CH:10]=[C:9]([N:12]3[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)[N:8]=[N:7][C:6]=2[N:5]([CH3:18])[C:4](=[O:19])[C:3]=1[C:20]([NH:22][CH2:23][C:24]([O:26]C(C)(C)C)=[O:25])=[O:21].OC1C2C=C(N3CCCCC3)N=NC=2N(C)C(=O)C=1C(OC)=O.Cl.NCC(OC(C)(C)C)=O>>[OH:1][C:2]1[C:11]2[CH:10]=[C:9]([N:12]3[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)[N:8]=[N:7][C:6]=2[N:5]([CH3:18])[C:4](=[O:19])[C:3]=1[C:20]([NH:22][CH2:23][C:24]([OH:26])=[O:25])=[O:21]

Participants

Reactant 3

HCID 2725036Glycine tert-butyl ester hydrochloride

HCID 66658647HCID 66658647, compound

HCID 66658750HCID 66658750, compound

Product 1

HCID 54741073HCID 54741073, compound

Procedure

tert-Butyl 2-(5-hydroxy-8-methyl-7-oxo-3-(piperidin-1-yl)-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxamido)acetate. The title compound is prepared by reaction of methyl 5-hydroxy-8-methyl-7-oxo-3-(piperidin-1-yl)-7,8-dihydropyrido[2,3-c]pyridazine-6-carboxylate and tert-butyl 2-aminoacetate hydrochloride according to Method 3(a).

Sources & evidence

ORD record: ord-c1b6b6e34e6540128af08f1d2b725d25
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08097620B2

Reaction notes

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