反应详情

Pouring 60 milliliter of acetic acid over 5.0 g (33 mmol) of N-methyl-2-nitroaniline and 5.9 g (33 mmol) of N-bromosuccinimide, the resultant solution was refluxed with heating for 7 hours. After completion of the reaction, the reacted solution was poured into 500 milliliter of water, and precipitated solids were separated with filtration. Dissolving the resultant solids into ethyl acetate, the resultant solution was dried with the use of magnesium sulfate. After filtration, the solvent was removed by distillation under reduced pressure, and after drying the solids under reduced pressure at room temperature, 7.1 g of 4-bromo-N-methyl-2-nitroaniline as orange solids were obtained (yield: 93%).

1. temperaturewith heating for 7 hours
2. customAfter completion of the reaction
3. customprecipitated solids
4. customwere separated with filtration
5. dissolutionDissolving the resultant solids into ethyl acetate
6. dry with materialthe resultant solution was dried with the use of magnesium sulfate
7. filtrationAfter filtration
8. customthe solvent was removed by distillation under reduced pressure
9. customafter drying the solids under reduced pressure at room temperature