HCID 85997294, compound → HCID 23094069, compound

Participants

Reaction Steps

Suspending 3.1 g (8.4 mmol) of 5′-bromo-2′-(N-phenylamino)-picoline anilide obtained in the above step (1) into 30 milliliter of xylene, and adding 0.48 g (2.5 mmol) of p-toluenesulfonic acid 1 hydrate, the resultant solution was azeotropically dehydrated while refluxing with heating for 5 hours. The reacted solution was cooled down to room temperature, and the solvent was removed by distillation. Dissolving the resultant solid into ethyl acetate, and after sequentially washing with water, with 10% potassium carbonate aqueous solution and with saturated solution of sodium chloride, it was dried with the use of magnesium sulfuric anhydride, followed by removing the solvent by distillation under reduced pressure, 2.0 g of 5-bromo-1-phenyl-2-(2-pyridyl)-1H-benzimidazole was obtained (yield: 69%).

Provenance & Evidence