HCID 57906440, compound → HCID 57906603, compound

Participants

Reaction Steps

The cyclization was carried out as described for Example 6 from (2-amino-5-bromo-pyridin-4-ylmethyl)-carbamic acid tert-butyl ester (600 mg, 2.0 mmol, prepared according to Example 1, Step 1.3) and 1,2-bis-benzotriazol-1-yl-N,N′-bis-(2-methoxy-ethyl)-N,N′-dimethyl-ethane-1,2-diamine (871 mg, 2.0 mmol, prepared according to Example 6, Step 3.1). After the work-up, the crude was purified by Combi-Flash Companion™ (Isco Inc.) column chromatography (SiO2; gradient elution, [hexane/DCM 1:1]/TBME (containing 0.5% of a 7.0 M solution of NH3 in MeOH) 1:0→0:1) to yield the title compound (546 mg, 1.32 mmol, 67%) as a brownish oil. MS: 414 [M−1]+; HPLC: AtRet=1.40; TLC—RF 0.15 (hexane/DCM/TBME (containing 0.5% of a 7.0 M solution of NH3 in MeOH) 1:1:2).

Provenance & Evidence