反应详情

温度

150 °C

In a schlenck tube, a mixture of 3-iodobenzohydrazide (510 mg, 1.95 mmol) and 1,1,1-triethoxyethane (1.14 ml, 6.23 mmol) in acetic acid (15 ml) was heated at 150° C. for 3 h. The solvent was evaporated and the crude redissolved in ethyl acetate and washed with 4% solution of NaHCO3, water and brine. The organic layer was dried, filtered and concentrated under vacuum to give the title compound as a white solid (92% yield).

1. customThe solvent was evaporated
2. dissolutionthe crude redissolved in ethyl acetate
3. washwashed with 4% solution of NaHCO3, water and brine
4. customThe organic layer was dried
5. filtrationfiltered
6. concentrationconcentrated under vacuum