1,4-Dioxane hydrochloride → HCID 66658027, compound

HRID 420555Notes

Reaction equation

HRID 420555 reaction equation
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:20][CH2:19][N:18]([C:21]2[S:22][C:23]3[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:24]=3[N:25]=2)[CH2:17][CH2:16]1)=O)(C)(C)C>>[ClH:30].[ClH:1].[Cl:30][C:28]1[CH:27]=[CH:26][C:24]2[N:25]=[C:21]([N:18]3[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]3)[S:22][C:23]=2[CH:29]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57966248HCID 57966248, compound

Product 1

HCID 66658027HCID 66658027, compound

Conditions

Temperature
60 °C

Procedure

To 4N solution of hydrochloric acid-dioxane was added 4-(6-chlorobenzothiazole-2-yl)piperazine-1-carboxylic acid tert-butyl ester (1.50 g; 4.239 mmol). The mixture was stirred at 60° C. for 1 hour. The reaction solution was concentrated under reduced pressure and the residue was washed with ethyl acetate to give 4-(6-chlorobenzothiazole-2-yl)piperazine dihydrochloride as colorless crystal (1.40 g; 100%).

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. washthe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-3e7da4fb80bd48e9bd07d3a5499df23d
Source dataset
uspto-grants-2012_01
Patent number
US08097610B2

Reaction notes

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