HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 420567Generated: October 27, 2026
Dimethylformamide → 1-(5-Bromothiazole-2-yl)-3,5-dimethyl piperazine
https://huagongshe.com/reaction/420567
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,6-Dimethylpiperazine | HCID 66056 | — |
| Reactant | 2,5-Dibromothiazole | HCID 312394 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(5-Bromothiazole-2-yl)-3,5-dimethyl piperazine | HCID 66657911 | 64.4% |
Reaction Steps
A mixture of 2,5-dibromothiazole (29.5 g), 2,6-dimethyl piperazine (13.8 g), potassium carbonate (20.1 g) and dimethylformamide (150 mL) was stirred at 60° C. for 6 hours. To the reaction solution was added water and extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over sodium sulphate. The solvent was evaporated under reduced pressure to give the title compound (21.5 g). Yield: 64%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08097610B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-9c5ae5c80b0f45c39ac6c1c9530de267 |
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| Source note | uspto-grants-2012_01 |
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