HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 42057Generated: October 31, 2026
Sodium Hydroxide → 5-Cyclopropyl-2-(6-methoxy-5-phenylpyridin-3-ylamino)benzoic acid
https://huagongshe.com/reaction/42057
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 5-cyclopropyl-2-(6-methoxy-5-phenylpyridin-3-ylamino)benzoate | HCID 67396504 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ammonia methanol | HCID 21705897 | — |
| Product | 5-Cyclopropyl-2-(6-methoxy-5-phenylpyridin-3-ylamino)benzoic acid | HCID 25186449 | 77% |
Reaction Steps
The solid residue obtained in step A was dissolved in 2.5 ml of ethanol and 0.180 ml of aqueous solution 2N NaOH were added. The mixture was heated at 60° C. for 2 hours, the solvent was evaporated and the solid obtained was suspended in water. The pH was taken to 6.5 and extracted with CHCl3. The crude mixture was purified over a SCX cartridge eluting with MeOH/NH3 10:1 affording 0.025 g (yield 77%) of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08536165B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-809ac7c483c042138138339ab910d6cd |
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| Source note | uspto-grants-2013_09 |
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