反应详情

温度

60 °C

The solid residue obtained in step A was dissolved in methanol (3 ml) and aqueous solution 2N NaOH (1 ml) was added. The mixture was heated at 60° C. for 2 hours, the solvent was evaporated and the solid obtained was suspended in water. The pH was taken to 6.5 and extracted with CHCl3. The crude mixture was purified over a SiO2 eluting with DCM/MeOH 2% affording 0.170 g (yield 81%) of the expected product.

1. customthe solvent was evaporated
2. customthe solid obtained
3. extractionextracted with CHCl3
4. customThe crude mixture was purified over a SiO2 eluting with DCM/MeOH 2%