Methanol → Methyl 2-methyl-3-nitrobenzoate

HRID 420612Notes

Reaction equation

HRID 420612 reaction equation
[CH3:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH3:19]O>>[CH3:19][O:5][C:4](=[O:6])[C:3]1[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:2]=1[CH3:1]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 160962-Methyl-3-nitrobenzoic acid

Product 1

HCID 601165Methyl 2-methyl-3-nitrobenzoate

Procedure

30 g (165.6 mmol) of 2-methyl-3-nitrobenzoic acid is added to 150 ml of methanol, and it is refluxed for two days after 2.9 ml of concentrated sulfuric acid is added. After cooling, the crystallizate (25.55 g=79%) is suctioned off and used in the next stage.

Workup

  1. additionis added
  2. temperatureAfter cooling

Sources & evidence

ORD record
ord-0dd2eb5bff81479c8572072c19d77542
Source dataset
uspto-grants-2012_01
Patent number
US08097627B2

Reaction notes

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