HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 5-Amino-1,2-dihydroquinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 5-Nitro-1,2-dihydroquinolin-2-one | HCID 243776 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Amino-1,2-dihydroquinolin-2-one | HCID 15719078 | 100.3% |
Reaction Steps
4.5 g of 5-nitroquinolin-2(1H)-one (Chem. Pharm. Bull., 29, 651 (1981)) is hydrogenated in 200 ml of ethyl acetate and 500 ml of methanol in the presence of 450 mg of palladium on activated carbon as a catalyst under normal pressure with hydrogen until the reaction is completed. The catalyst is removed by filtration through diatomaceous earth, and the reaction solution is concentrated by evaporation in a vacuum. 3.8 g of the title compound is obtained as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097627B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-9a77856c67614cb68cbd1c4187a002ae |
| Source note | uspto-grants-2012_01 |