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Water → 3-Bromo-4-nitrophthalide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 4-Nitrophthalide | HCID 1211692 | — |
| 触媒 | Benzoyl Peroxide | HCID 7187 | — |
| 溶媒 | (Trifluoromethyl)benzene | HCID 7368 | — |
| 生成物 | 3-Bromo-4-nitrophthalide | HCID 17985038 | 93.6% |
反応手順
5.37 g of 4-nitrophthalide (Tetrahedron Lett. (2001), 42, pp. 1647-50), 8.04 g of N-bromosuccinimide, and 196 mg of benzoyl peroxide are refluxed in 80 ml of benzotrifluoride and exposed to light until the reaction is completed. It is added to water, extracted with dichloromethane, washed several times with water, dried, and the solvent is removed in a vacuum. 7.24 g of 3-bromo-4-nitro-phthalide is obtained as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08097627B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-163bc53a0f1542abb20f79a340dc87c8 |
| 出典メモ | uspto-grants-2012_01 |