HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Methyl-5-nitrophthalazin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Nitrophthalazin-1(2H)-one | HCID 20323190 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Methyl-5-nitrophthalazin-1-one | HCID 17989125 | 91.4% |
Reaction Steps
1.6 g of 5-nitro-phthalazin-1-one and 2.31 g of potassium carbonate are stirred for 10 minutes at room temperature in 60 ml of DMF. 1.1 ml of methyl iodide is added, and it is stirred overnight. It is added to water, extracted several times with ethyl acetate, and the organic phase is washed with water and brine. It is dried, and the solvent is removed in a vacuum. 1.57 g of 2-methyl-5-nitro-phthalazin-1-one is obtained as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097627B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-93cf40f92d47401c9f4a9ae6e81da65c |
| Source note | uspto-grants-2012_01 |