HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-5-nitrophthalazin-1-one → 5-Amino-2-methylphthalazin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-5-nitrophthalazin-1-one | HCID 17989125 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Amino-2-methylphthalazin-1-one | HCID 17985045 | 94% |
Reaction Steps
1.57 g of 2-methyl-5-nitro-phthalazin-1-one and 130 mg of palladium on activated carbon are suspended in 45 ml of ethyl acetate and hydrogenated with hydrogen under normal pressure. It is filtered through diatomaceous earth, and the solvent is removed in a vacuum. 1.26 g of 5-amino-2-methyl-phthalazin-1-one is obtained as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097627B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-9cd130f40a63452b89d514ecc6a81af4 |
| Source note | uspto-grants-2012_01 |