HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → Lithium 3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Ethyl 3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propanoate | HCID 3651864 | — |
| Solvent | Water | HCID 962 | — |
| Product | Lithium 3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propanoate | HCID 23693664 | — |
Reaction Steps
To a tetrahydrofuran (350 ml) solution of ethyl 3-oxo-3-{[3-(trifluoromethyl)phenyl]amino}propanoate (5 g, 18.17 mmol) (Example 1A) is added lithium hydroxide (435 mg, 18.17 mmol) in water (150 ml). The solution is stirred at room temperature for 4 hours, and then concentrated to afford a white solid. The crude product is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097629B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-7caa9bac3510457781c6753dbcb19315 |
| Source note | uspto-grants-2012_01 |