Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid → 4-(2-Acetyl-3-oxo-1-butenyl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 1,4-Dicyanobenzene | HCID 12172 | — |
| 반응물 | Acetylacetone | HCID 31261 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-(2-Acetyl-3-oxo-1-butenyl)benzonitrile | HCID 367453 | — |
반응 단계
A solution of 4-cyanobenzonitrile (20 g, 0.15 mol), 2,4-pentanedione (17 g, 0.17 mol), piperidine (130 mg, 1.5 mmol) and p-toluene sulfonic acid (260 mg, 1.5 mmol) in toluene (400 ml) is refluxed overnight with a Dean-Stark trap. The solution is concentrated in vacuo and purified over silica gel with cyclohexane/ethyl acetate mixtures as eluent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08097629B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-177978b6479745208fbd5a3de45c58d4 |
| 출처 메모 | uspto-grants-2012_01 |