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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 420654Generated: October 27, 2026

3,3-Dimethylbutanoyl chloride → 8-(3,3-Dimethyl-butyryl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-1,7-dione

https://huagongshe.com/reaction/420654

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,3-Dimethylbutanoyl chlorideHCID 81514—
Reactant2-(4-Trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-1,7-dioneHCID 58478411—
Product8-(3,3-Dimethyl-butyryl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-1,7-dioneHCID 53482624—

Reaction Steps

This material was prepared as a white solid in analogy to example 3 from 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-1,7-dione, product of example 1 step D), and 3,3-dimethyl-butyryl chloride. MS (ESI): 427.1 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08097634B2
Source datasetuspto-grants-2012_01
ORD IDord-1f94f25356774ff084bd2e2ed720b367
Source noteuspto-grants-2012_01