HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2,2,2-Trifluoroethyl)aniline → 2-(4-(2,2,2-Trifluoroethyl)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2,2,2-Trifluoroethyl)aniline | HCID 14836858 | — |
| Reactant | 4-(2-Methoxy-ethyl)-2-oxo-piperidine-4-carboxylic acid ethyl ester | HCID 58478414 | — |
| Solvent | Dimethylalumanylium chloride | HCID 16686359 | — |
| Product | 2-(4-(2,2,2-Trifluoroethyl)phenyl)-2,8-diazaspiro[4.5]decane-1,7-dione | HCID 58478415 | — |
Reaction Steps
This material was prepared as a white solid (0.72 g) in analogy to example 1 step D) from 4-(2-methoxy-ethyl)-2-oxo-piperidine-4-carboxylic acid ethyl ester (1.03 g), dimethylaluminium chloride (0.9 M in hexane, 20 ml) and 4-(2,2,2-trifluorethyl)aniline (1.2 g). MS (ESI): 327.13 (MH−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097634B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-ce04ced86279441390ddddb62529c0e4 |
| Source note | uspto-grants-2012_01 |