反应详情

MnO2 (165 mg, 1.903 mmol) was added to a solution of 5-(hydroxymethyl)-3-methyl-2-pyridinecarbonitrile (28.2 mg, 0.190 mmol) in DCM (2 ml) at rt and the mixture was stirred at that temperature overnight. LCMS showed the starting material was gone. The solids were filtered off and the solvent evaporated. 5-Formyl-3-methyl-2-pyridinecarbonitrile (20.2 mg) was obtained impure. It was used in the next step without prior purification.

1. filtrationThe solids were filtered off
2. customthe solvent evaporated