Tetrabutylammonium Fluoride → HCID 58001743, compound

Participants

Reaction Steps

To a solution of 2-[3-chloro-5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2-propanol (328 mg, 1.038 mmol) in THF (10 ml) was added TBAF (1.557 ml, 1.557 mmol). The solution was stirred at room temperature for 3 h. The mixture was concentrated under vacuum and the residue was purified by Flashmaster chromatography on a 40 g Merk silica gel cartridge using DCM/MeOH 95:5 as eluent to obtain 2-[3-chloro-5-(hydroxymethyl)-2-pyridinyl]-2-propanol (210 mg, 95%) as colourless oil.

Provenance & Evidence