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HRID42075

反应详情

EQUATION

反应方程式

HRID 42075 的结构方程式

REACTANTS

反应物

2
结构：Cl.Cl.NO[C@@H]1CCNC1
HCID66713918

未命名化合物

结构：C[C@H]1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)CCC(=O)CC12
HCID69007982

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)CCC(=NO[C@@H]3CCNC3)CC12.Cl
HCID86635556

未命名化合物

收率 70%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Prepared in 70% yield as described in Example 1 starting from 6α-methylandrostane-3,17-dione (II-ai, Prepn. 19) and 3-(R)-pyrrolidinyloxyamine dihydrochloride (III-e, Prepn. 5). The crude product was dissolved in H2O and freeze-dried to give the title compound I-ax. 1H-NMR (300 MHz, DMSO-d6, ppm from TMS): δ 9.03 (2H, bb), 4.73 (1H, m), 3.30-3.02 (5H, m), 2.45-0.56 (22H, m), 0.87 (3H, m), 0.84 (3H, s), 0.78 (3H, s).

WORKUP

后处理

  1. customPrepared in 70% yield
  2. customfreeze-dried