HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 2-chloro-4-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Chloro-4-methylbenzoic acid | HCID 2735755 | — |
| Product | Methyl 2-chloro-4-methylbenzoate | HCID 22019481 | — |
Reaction Steps
2-chloro-4-methylbenzoic acid (500 mg, 2.93 mmol) was dissolved in Methanol (7 mL) and SOCl2 (0.215 mL, 2.93 mmol) was slowly added to the mixture and the reaction was left at room temperature overnight. Next morning HPLC showed completion. Volatiles were removed under vacuum to afford 526 mg of the title compound as brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097628B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-816d5ce1e99a4848bd036311ac824933 |
| Source note | uspto-grants-2012_01 |