反应详情

Methyl 2-chloro-4-methylbenzoate (520 mg, 2.82 mmol) was dissolved in Dichloromethane (DCM) (15 mL) and at 0° C. Dibal-H (4.694 ml, 7.04 mmol) was slowly added. The mixture was left at 0° C. for 2H and then at room temperature overnight. Next morning HPLC showed no starting material remaining, reaction was quenched with Rochelle salt, and leaving under stirring for 1 hour and then it was extracted with DCM, dried and concentrated to afford 365 mg of the final compound, pure enough to be used in the next step.

1. waitThe mixture was left at 0° C. for 2H
2. customat room temperature
3. customovernight
4. customreaction
5. customwas quenched with Rochelle salt
6. customleaving
7. extractionit was extracted with DCM
8. customdried
9. concentrationconcentrated