HCID 57577327, compound → 4-[(Tetrahydro-3-furanyl)oxy]cyclohexanol

Participants

Reaction Steps

4-(Tetrahydro-furan-3-yloxy)-phenol (900 mg, 5.00 mmol) was dissolved in 25 ml 0.4N NaOH and stirred with 500 mg Rh/C 5% under hydrogen atmosphere at 60° C. and 4 bar pressure for 3 hours. The catalyst was filtered off and the clear solution acidified with conc. H2SO4 to pH 1. The aqueous layer was saturated with NaCl and extracted two times with dichloromethane. The organic extracts were dried with sodium sulfate, filtered and evaporated. The crude product (800 mg, 86%) was obtained as a light brown liquid and used without any further purification for the next step.

Provenance & Evidence