HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Piperidyloxyamine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-(aminooxy)piperidine-1-carboxylate | HCID 24729482 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Piperidyloxyamine dihydrochloride | HCID 10313449 | — |
Reaction Steps
1-tert-Butoxycarbonyl-4-piperidyloxyamine (120 mg) was dissolved in a 5M HCl solution in EtOAc (3 mL). After 1 h the solvent was removed under reduced pressure to give the title compound III-a (100 mg, 96%). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS): δ 10.95 (3H, bb), 8.96 (2H, bb), 4.33 (1H, m), 3.13 (2H, m), 3.00 (2H, m), 2.09 (2H, m), 1.85 (2H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536160B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-4f1d3b8d0921442ebe3202700f85034e |
| Source note | uspto-grants-2013_09 |