HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 6,7-Dichloro-1,2,3,4-tetrahydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 12595078 | HCID 12595078 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6,7-Dichloro-1,2,3,4-tetrahydroisoquinoline | HCID 12595077 | 100.7% |
Reaction Steps
6,7-dichloro-1,2,3,4-tetrahydroisoquinoline HCl salt (550 mg, 2.31 mmol) was dissolved in water (5 mL) and DCM (20 mL). Aqueous saturated NaHCO3 (10 mL) was added and the organic phase was separated. The aqueous phase was extracted twice with DCM (20 mL), the organic phases were combined, dried (Na2SO4), and filtered to give 6,7-dichloro-1,2,3,4-tetrahydro-isoquinoline (470 mg, quant.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097636B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-2d46b5ffb69548b0a33cbe121da15847 |
| Source note | uspto-grants-2012_01 |