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General Procedure E. A solution of ethyl 1-benzyl-5-hydroxy-2-isopropyl-1H-indole-3-carboxylate (Compound 1, 1.1 g, 3.3 mmol) and NaOH (2.6 g, 65 mmol) in EtOH (20 ml) and H2O (10 ml) was heated to 100° C. for 16 h. The solvent was removed and the residue was treated with cold 6 M HCl (10.8 ml) and filtered. The resulting solid was washed with H2O (×3) and was taken in Et2O (∴3) to yield 1-benzyl-5-hydroxy-2-isopropyl-1H-indole-3-carboxylic acid (Compound 28) as a brown solid.

1. customThe solvent was removed
2. additionthe residue was treated with cold 6 M HCl (10.8 ml)
3. filtrationfiltered
4. washThe resulting solid was washed with H2O (×3)