HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 420815Generated: October 31, 2026
HCID 66658583, compound → 2-Isopropyl-1H-indole
https://huagongshe.com/reaction/420815
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 66658583 | HCID 66658583 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Isopropyl-1H-indole | HCID 87307 | — |
Reaction Steps
To a solution of 2-(3-methylbut-1-ynyl)aniline (Compound 37, 3.47 g, 21.8 mmol) in DMF (100 ml) was added copper (I) iodide (41 mg, 0.22 mmol). The mixture was stirred at 160° C. for 2 h and was concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with 5% EtOAc-hexanes to yield 2-isopropyl-1H-indole (Compound 38) as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08097644B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-992fd5af865b4605ba207428b6255660 |
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| Source note | uspto-grants-2012_01 |
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