HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 420821Generated: October 28, 2026
Ethyl 4-hydroxy-3-iodobenzoate → Ethyl 3-cyano-4-hydroxybenzoate
https://huagongshe.com/reaction/420821
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl 4-hydroxy-3-iodobenzoate | HCID 11220038 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Ethyl 3-cyano-4-hydroxybenzoate | HCID 21322395 | 76% |
Reaction Steps
Dissolve ethyl 4-hydroxy-3-iodo-benzoate (45 g, 154.1 mmoles) in DMSO (125 mL). Add CuCN (15.17 g, 169.5 mmoles). Stir the mixture at 100° C. overnight. After cooling, pour the mixture into ice/water. Filter the solid obtained, wash with water and dry under reduced pressure. Dissolve the solid in EtOAc. Filter through Celite®. Dry over MgSO4 and remove the solvent to obtain 22.36 g of ethyl 3-cyano-4-hydroxy-benzoate (76% yield). MS(ES): m/z=190.0 [M-H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08097652B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-c0263a296f6046a988f7b1e82a495214 |
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| Source note | uspto-grants-2012_01 |
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