反应详情

Charge to an autoclave hydrogenation apparatus under nitrogen water-wet 5% palladium on carbon (453 g), ethanol (6.36 L), 2-phenylpropionitrile (636 g, 4.85 moles) and finally concentrated (12M) hydrochloric acid (613 g, 5.6 mole). Stir the mixture rapidly and pressurize to 75 to 78 psi with hydrogen. Heat the mixture 50° C. to 64° C. for 3 hours. Depressurize and filter the reaction mixture to afford two lots of filtrate. Concentrate filtrates under reduced pressure to approximately 400 mL each. Add methyl tert-butyl ether (MTBE) (2.2 L each) to each lot. Stir the precipitate overnight. Filter and wash solids with fresh MTBE (100 mL) and dry overnight. Combine the lots to afford 2-phenyl-1-propylamine HCl (634.4 g, 76.2%) as a white powder.

1. additionCharge to an autoclave hydrogenation apparatus under nitrogen water-wet 5% palladium on carbon (453 g)
2. temperatureHeat the mixture 50° C. to 64° C. for 3 hours
3. filtrationDepressurize and filter the reaction mixture
4. customto afford two lots of filtrate
5. stirringStir the precipitate overnight
6. filtrationFilter
7. washwash solids with fresh MTBE (100 mL)
8. customdry overnight