1-Octanol → HCID 86623588, compound

HRID 420832Notes

Reaction equation

HRID 420832 reaction equation
P([O-])([O-])([O-])=[O:2].[CH2:6]([OH:14])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]>>[CH2:6]([OH:14])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[OH2:2]

Participants

3

Reactant 2

HCID 9571-OctanolHCID 1061Phosphate

Product 1

HCID 86623588HCID 86623588, compound

Procedure

Equal amounts of octanol and a phosphate buffer were mixed together and [125I]I-BzA-TBOA was added thereto. After repeatedly shaking for 1 minute and allowing to stand for 1 minute three times, the mixture was allowed to stand for 20 minutes. After repeating this procedure three times, it was centrifuged (1,000×g, 10 min, 4° C.) and the radioactivity of each layer was measured. Thus, the partition coefficient was calculated (Table 1).

Workup

  1. waitto stand for 1 minute
  2. waitto stand for 20 minutes
  3. custom(1,000×g, 10 min, 4° C.)

Sources & evidence

ORD record
ord-94c4eadbedcd40abbe0165a7ba0bc2bc
Source dataset
uspto-grants-2012_01
Patent number
US08097654B2

Reaction notes

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