N-(4-Bromobutyl)phthalimide → HCID 66658329, compound

HRID 420854Notes

Reaction equation

HRID 420854 reaction equation
[NH2:1][C@@H:2]([CH2:14][OH:15])[C@H:3]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1)[OH:4].Br[CH2:17][CH2:18][CH2:19][CH2:20][N:21]1C(=O)C2=CC=CC=C2C1=O>>[NH2:21][CH2:20][CH2:19][CH2:18][CH2:17][NH:1][C@H:2]([CH2:14][OH:15])[C@@H:3]([C:5]1[CH:6]=[CH:7][C:8]([N+:11]([O-:13])=[O:12])=[CH:9][CH:10]=1)[OH:4]

Participants

3

Reactant 2

HCID 93575N-(4-Bromobutyl)phthalimideHCID 2241712964-48-9

Product 1

HCID 66658329HCID 66658329, compoundYield 68.9%

Procedure

By using (1S,2S)-(+)-2-amino-1-(4-nitrophenyl)-1,3-propanediol (3.0 g) and N-(4-bromobutyl)phthalimide (4.77 g) as starting materials, the title compound (2.76 g) was obtained in the same manner as that of Reference Example 139.

Sources & evidence

ORD record
ord-5cffe131679647a1a01d066def78b38b
Source dataset
uspto-grants-2012_01
Patent number
US08097708B2

Reaction notes

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